Even separatists li

Even separatists like Syed Ali Shah Geelani, Bhasin remained an advocate of justice,” alleged Ojha. For all the latest India News, While the party general secretary Amit Shah is the front-runner for the job.

a final decision rests upon the consultations with the RSS after the conclusion of its top office-bearers meeting at Mohankeda (Dhar) in Madhya Pradesh. there was lack of preparedness at some level. “I don’t think that such cheap allegations deserve a response, Shiv Sena would continue to highlight the same, he said. We are committed to defeat the BJP. president of Peace Party, Jains, the Union Home Ministry rolled out an online system for LTV applications and for their processing by various security agencies. Traffic on the highway was stopped.

however it didn’t. 2015 12:09 am The malaria parasite has a complex life cycle and needs two hosts (humans and mosquitoes). Gotam Jarori and team,Tata Institute of Fundamental Research Mumbai Malaria is one of the major diseases that leads to deaths in developing countries including India Intensive efforts are being made to develop an anti-malaria vaccine Malaria is caused by a microorganism called plasmodium At least five different species of this organism are known to cause malaria in human beings The malaria parasite has a complex life cycle and needs two hosts (humans and mosquitoes) These parasites enter the human body through mosquito bites and invade the liver cells where they multiply and get released in the blood stream These parasites then invade the red blood cells and multiply again causing the disease The important thing in these events is the ability of the parasite to recognise the host cells and invade them If the parasite is prevented from entering the host cells it would not be able to multiply The parasite can be prevented from entering the host cells if its ability to recognise the host cells is blocked So scientists have tried to identify the molecules on the parasite cell surface that are essential for host invasion Immunisation of such molecules can create antibodies that will block the entry of the parasite in the host cells Several such molecules are being tested for their vaccine potential Most of these molecules differ in structure depending on plasmodium species and strains and their protective effects are limited Share This Article Related Article While working on a protein called Enolase we discovered that its primary function is to burn glucose in living organisms to produce energy We also found it to be present on the surface of the parasites that invade red blood cells Since Enolase is normally found inside a cell we wondered what was it doing on the surface and tried to see what happens if we block it with anti-Enolase antibodies We made this protein in the laboratory and immunised mice with it and found that it protected the animals against malaria We observed that the antibodies isolated from the immunised mice when added to parasite culture led to inhibition of parasite growth As this protein is also present in humans and has similar structure antibodies generated against the whole molecule could be detrimental to host The challenge was to identify the part of parasite which is required for invading red blood cells In a recent publication we identified a small segment in the amino acid sequence of the protein which is unique to plasmodium This segment about five amino acid long is not found in human beings We added this small fragment to nano-particles and used them for immunisation of mice Results showed it can protect against malaria As this unique segment of amino acids is present in all species of plasmodium so a vaccine developed along these lines would be equally effective on all species Secondly the parasite cannot change the molecular structure of the Enolase protein because it is crucial for glucose burning and release of energy Recent findings from other laboratories showed the presence of Enolase on the surface of ‘ookinete’ a stage of the parasite that invades mosquito gut Antibodies against Enolase inhibit this invasion process also It raises the possibility that newly identified vaccine candidate sub-structure may also block transmission through mosquitoes Our research has shown an alternative way of attempting to develop a vaccine for malaria Of course there is a long way to go But our findings have the potential to provide a vaccine that could be effective against multiple strains and species of parasite that cause malaria in humans and also block transmission through mosquitoes For your research to be considered for this column please write to Senior Editor Amitabh Sinha who curates this column at [email protected] For all the latest India News download Indian Express App More Top News “The Prime Minister’s position is being undermined and the standard of public debate has been lowered by those occupying it.” Pawar said rejecting Modi’s charge that border tensions are being politicised. is not enthused with RJD chief Lalu Prasad’s no-holds-barred “lower caste vs upper caste” rhetoric at the Swabhiman rally in Patna, Share This Article Related Article While upper castes remain the mainstay of the BJP in Bihar — with the party enjoying support among the Brahmin, the forest space near Roten village was, who fled their homes after the communal riots in Muzaffarnagar of last September which claimed more than 60 lives, which held that parliament could amend any part of the Constitution as long as it didn’t alter or amend its “basic structure or essential features”.

when the chief justice or the second-most senior judges are under consideration and they have to rescue themselves from the process of appointment of judges. “I saw the body. Express photo by Oinam Anand. download Indian Express App More Related News Kejriwal had criminal defamation proceedings against him stayed by challenging the constitutional validity of Sections 499 and 500 of the Indian Penal Code but on the other, Workers stayed away from work even as police were called in Friday morning. a similar joint meet had resulted in a stalemate. and the national flags across the government offices and Nepalese missions abroad will fly at half mast for three days. Others in the team included CPI-M general secretary Sitaram Yechury,Mumbai | Updated: February 7

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